Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?

Description: Information on transformation and persistence of chemical substances in the environment is important for hazard and risk assessment within a regulatory context or as a decision criterion in a safe and sustainable by design framework. Half-lives for human and veterinary medicinal products available from marketing authorization applications were compared between soil (OECD 307) and aquatic water/sediment systems (OECD 308). The comparison shows, that there is no obvious correlation between the total system half-lives in the two different compartments and that surpassing persistence criteria is compartment-specific in 45% of the cases. © The Author(s) 2023

Global identifier:

Doi(
    "10.60810/openumwelt-2180",
)

Origin: /Bund/UBA/openUMWELT

Tags: Tierarzneimittel ? Blei ? OECD ? Halbwertszeit ? Aquatisches Ökosystem ? Studie ? Ökodesign ? Persistenz ? Chemischer Stoff ? Risikobewertung ?

License: other-closed

Language: Englisch/English

Issued: 2023-01-01

Time ranges: 2023-01-01 - 2023-01-01

Status

Aktiv

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