New-Generation Steroid Hormones

Description: The project generated ecotoxicological data needed for the development of a tailored testing strategy to assess the environmental risk of pharmaceuticals (progestins and glucocorticoids). For this purpose, chronic fish tests, among others, were carried out in the laboratory according to a new test protocol currently undergoing ⁠OECD⁠ validation investigating dienogest and dexamethasone as test substances. The studies provided reliable and valid results with effect thresholds in the lower µg/L or ng/L range. This has closed data gaps for the development of new assessment approaches for a targeted risk assessment of specifically acting pharmaceuticals. Additional investigations on directed gene expression and immunosuppressive effect assays would complement the assessment strategy for progestins and glucocorticoids.

Global identifier:

Doi(
    "10.60810/openumwelt-6129",
)

Types:

Origin: /Bund/UBA/openUMWELT

Tags: Biologische Wirkung ? Fischtest ? OECD ? Steroid ? Chemikalien ? Daten ? Hormon ? Studie ? Testsubstanz ? Umweltgefährdung ? Umweltrisikobewertung ? Endokrin aktive Substanz ? Risikobewertung ? ecotoxicology ?

License: unbekannt

Language: Englisch/English

Organisations

• Umweltbundesamt (Herausgeber*in)

Issued: 2024-01-01

Time ranges: 2024-01-01 - 2024-01-01

Status

Aktiv

Quality score

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• Interoperability: 0.25

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• Reusability: 0.33

  • License: NoInformation (0.00)
  • Contact info: false
  • Publisher info: true

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