Description: Das Projekt "PCB-Kontakt in der Umwelt und Entwicklungsdefizite: Funktionen des Neuroverhaltens nach dem Alter von 18 Monaten bis ins Schulalter" wird vom Umweltbundesamt gefördert und von Universität Düsseldorf, Medizinisches Institut für Umwelthygiene durchgeführt. Design of Study: In this study existing cohorts will be followed in two parts covering the upper age limits of 42 months (Part I: Duesseldorf, Faroe Islands) and 72 months (Part II: Dutch groups), respectively. Within each of these segments between 300 - 400 children will be studied. PART I (Duesseldorf, Faroe Islands): In this section of the follow-up study cohorts from Duesseldorf (N = 150-180) and the Faroe Islands (N = 160-190) will be retested at ages 30 and 42 months. The overall sample size is expected at about 312 at age 30 months and 295 at 42 months of age. The basic independent variables are PCB-levels in plasma and in maternal milk, as available from the ongoing prospective studies. Additional PCB-levels will be measured at age 42 months. Main functions tested include neurology, language and cognitive development (Bayley, Kaufmann and Stanford-Binet). PART II (Groningen, Rotterdam): In this part of the follow-up study the cohorts from Groningen (N = 212) and Rotterdam (N = 207), each of them subdivided into 50 per cent formula-fed and breastfed babies, will be retested at schoolage (6 years), after having already been retested at age 3 1/2 years (42 month) previously. Again, the basic independent variables are prenatal PCB-concentrations (cord blood, maternal blood) and early postnatal levels in maternal milk as measured during the early stages of recruitment between 1989 and 1991; PCB-levels in serum are also available from the 42 months examination, and will also be measured at 6 years of age. Main dependent variables are neurology, cognitive developement (Kaufman Scales) and behaviour ratings (Child Behaviour Check List). Statistical data analysis for PART I and PART II: Apart from desciptive summary data the main part of the overall analysis will be based on multiple logistic regression-models for binary data, and on multiple linear regression-models for continuous data. Adjustment for relevant confounders, as eg social status, obstetrical optimality, maternal IQ and quality of the home environment, will be an important aspect of final statistical modelling. Particular care is taken to also consider co-exposure to other neurotoxicant chemicals, as eg lead (German and Dutch studies) and methylmercury (Danish/Faroe Island study element).
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Hirsch ? Düsseldorf ? Methylquecksilber ? Rotterdam ? Polychlorierte Biphenyle ? Säugling ? Schadstoffwirkung ? Blei ? Island ? Main ? Blutuntersuchung ? Kind ? Neurotoxizität ? Insel ? Statistische Daten ? Blut ? Chemikalien ? Langzeituntersuchung ? Muttermilch ? Risikoanalyse ? Statistische Analyse ? Studie ? Umwelthygiene ? Modellierung ? Empirische Untersuchung ? Gesundheit ? Soziale Gruppe ? Schadstoff ? Schadensregulierung ?
Region: Nordrhein-Westfalen
Bounding box: 6.76339° .. 6.76339° x 51.21895° .. 51.21895°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 1996-05-01 - 1999-02-28
Accessed 1 times.