Development of methodology for alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics (NANOTEST)

Description: Das Projekt "Development of methodology for alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics (NANOTEST)" wird vom Umweltbundesamt gefördert und von Norwegian Institute for Air Research Kjeller durchgeführt. Objective: Nanoparticles (NP) have unique, potentially beneficial properties, but their possible impact on human health has not been adequately assessed. The main goal of this proposal is to develop alternative high-throughput testing strategies using in vitro and in silico methods to assess the toxicological profile of NP used in medical diagnostics. Our specific aims are to: 1. Define NP properties and fully characterize NP to be used 2. Study NP interactions with molecules, cells and organs and develop in vitro methods to study the toxicological potential of NP 3. Validate in vitro findings in short-term in vivo models and study particle effects in animals and (ex vivo) in humans to assess individual susceptibility to NP 4. Develop in silico models of NP interactions Experimental work is structured in 4 WPs to address NP characterisation and key elements in evaluation of NP uptake, exposure and toxicology. NANOTEST integrates the investigation of toxicological properties and effects of NP in several target systems by developing a battery of in vitro assays using cell cultures, organotypic cell culture and small organ fragments (ex vivo) derived from different biological systems; blood, vascular system, liver, lung, placenta, digestive and central nervous systems.

Types:

SupportProgram

Origin: /Bund/UBA/UFORDAT

Tags: Biopharmazeutikum ? Gesundheitsgefährdung ? Schadstoffwirkung ? Main ? Gesundheitliche Auswirkungen ? Batterie ? Schadstoffexposition ? Software ? Struktur-Wirkung-Beziehung ? Nanotoxikologie ? Nanotoxizität ? Risikoanalyse ? Organisches Gewebe ? in vitro ? Leber ? Lunge ? Medizin ? Mensch ? Nervensystem ? Prüfverfahren ? Quantitative Analyse ? Stoffbewertung ? Studie ? Tierversuch ? Toxikologie ? Toxikologische Bewertung ? Wirkungsanalyse ? Zelle ? Zellkultur ? Tier ? Modellierung ? Menschliche Gesundheit ? Nanopartikel ? Arbeitsschutz ? Blut ? Medizinprodukt ? Schnelltest ? Partikel ? Organ ? Wechselwirkung ? ex vivo ? Blutgefäß ? medical diagnostics ? Plazenta ? In-Vivo ? Validierung ? Interaktionsanalyse ? FP7-HEALTH ?

License: cc-by-nc-nd/4.0

Language: Deutsch

Organisations

• Advancell Advanced in Vitro cell Technologies S.A. (Mitwirkende)
• Commission of the European Communities, Directorate General Joint Research Centre (Mitwirkende)
• Hospices Cantonaux CHUV (Mitwirkende)
• Institute for Occupational Medicine (IOM) (Mitwirkende)
• Kommission der Europäischen Gemeinschaften Brüssel (Bereitsteller*in)
• National Center for Scientific Research Demokritos (Mitwirkende)
• Norwegian Institute for Air Research Kjeller (Betreiber*in)
• Slovenská zdravotnícka univerzita v Bratislave (Mitwirkende)
• Umweltbundesamt (Bereitsteller*in)
• Universita Venezia (Mitwirkende)
• Universite Paris VII (Mitwirkende)
• Universitet Köbenhavn (Mitwirkende)

Time ranges: 2008-04-01 - 2012-03-31

Alternatives

• Language: Englisch/English https://ufordat.uba.de/

Status

Aktiv

Quality score

• Overall: 0.38
• Findability: 0.36

  • Description: 0.31
  • Identifier: false
  • Keywords: 0.81
  • Spatial: NoRegion (0.00)
  • Temporal: true
• Accessibility: 0.50

  • Landing page: Unknown (0.00)
  • Direct access: false
  • Publicly accessible: true
• Interoperability: 0.00

  • Open file format: false
  • Media type: false
  • Machine-readable metadata: false
  • Machine-readable data: false
• Reusability: 0.67

  • License: ClearlySpecifiedAndFree (1.00)
  • Contact info: false
  • Publisher info: true

Accessed 1 times.