Description: Das Projekt "Comparison and validation of novel pyrogen tests based on the human fever reaction (HUMAN(E) PYROGEN TES)" wird vom Umweltbundesamt gefördert und von Steinbeis-Transferzentrum, In-Vitro Pharmakologie und Toxikologie durchgeführt. Pyrogen testing is a crucial safety control of drugs as well as innovative high- tech products such as medical, cellular therapies and species-specific agents (e.g. recombinant proteins). For most biologicals, especially blood-derived drugs, the rabbit animal experiment represents still the method of choice consuming hundreds of thousands animals in the EU per year. This test is laborious, expensive, raises ethical concerns and can not be applied for some of the new products. In recent years, in Europe a number of alternative cellular assays have been developed exploiting the human fever reaction, i.e. human leukocytes release inflammatory mediators in the presence of pyrogenic contamination. The suggested network brings together the most prominent test systems for trans-national comparison and subsequent validation of the most promising models as an integrated goal-oriented problem solving approach.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Biopharmazeutikum ? Arzneimittel ? Technologietransfer ? Brunnen ? Kaninchen ? Pharmakologie ? Therapie ? Typhus ? Arzneimittelsicherheit ? Abfallwirtschaft ? Biotechnologie ? in vitro ? Innovation ? Mensch ? Protein ? Tierversuch ? Toxikologie ? Tier ? Europa ? Gesundheit ? Produkt ? Verunreinigung ? Art [Spezies] ? Elite ? Life Sciences ? Mittel ? Sicherheitsüberprüfung ? mental Protection ?
Region: Baden-Württemberg
Bounding box: 9° .. 9° x 48.5° .. 48.5°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2000-02-01 - 2003-01-31
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