Description: Das Projekt "Understanding the ecology and virulence of Legionella spp. populations in freshwater systems in Germany, Palestine and Israel" wird vom Umweltbundesamt gefördert und von Helmholtz-Zentrum für Infektionsforschung GmbH durchgeführt. Bacteria of the genus Legionella cause waterborne infections resulting in severe pneumonia. In Europe, 70Prozent of the cases of the so-called Legionnaires disease (LD) originate from strains of L. pneumophila serogroup (Sg) 1, 20Prozent from other L. pneumophila serotypes and 10Prozent from other Legionella species. In contrast, in the Middle East most legionella infections are due to L. pneumophila Sg3. The overall objective of this project is to advance current knowledge on the ecology of legionella in freshwater systems, the environmental factors affecting their occurrence, virulence potential and infectivity and to understand their transmission to humans. We will analyze the major environmental factors regulating the abundance of legionella, such as grazing and assimable dissolved organic carbon, because the occurrence of these heterotrophic bacteria in aquatic habitats is highly dependent on these factors. We will use an integrated molecular approach based on highresolution diagnostics of environmental samples and clinical isolates to determine the abundance, activity and virulence potential of Legionella populations in-situ. Combining environmental and molecular epidemiological data, we aim at understanding the link between ecology and population dynamics of legionella and cases of LD. The project will result in a novel understanding of the molecular epidemiology of legionella and provide new surveillance tools and strategies to prevent LD.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Populationsdynamik ? Populationsökologie ? Ökologie ? Bundesrepublik Deutschland ? Israel ? Palästina ? Legionella pneumophila ? Habitat ? Hydrogeologie ? Lungenerkrankung ? Süßwasser ? Bakterien ? Gelöster organischer Kohlenstoff ? Naher Osten ? Molekulare Epidemiologie ? Beweidung ? Daten ? Epidemiologie ? Hydrobiologie ? Hydrochemie ? Limnologie ? Monitoring ? Siedlungswasserwirtschaft ? Pathogenität ? Wasserverschmutzung ? Legionellen ? Europa ? Mittlerer Osten ? Population ? Krankheit ? Krankheitserreger ? Bevölkerung ? Hydrologie ? in situ ? Infektion ? Ökologischer Faktor ? Transmission ? Überwachung ? Werkzeug ? Art [Spezies] ?
Region: Lower Saxony
Bounding box: 9.16667° .. 9.16667° x 52.83333° .. 52.83333°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2011-01-01 - 2024-11-29
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