Description: Das Projekt "The development, validation and implementation of human systemic Toxic Equivalencies (TEQs) as biomarkers for dioxin-like compounds (SYSTEQ)" wird vom Umweltbundesamt gefördert und von Universität Utrecht durchgeführt. Objective: Chlorinated dioxins and biphenyls (PCBs) commonly occur in the human food chain and can still be detected at levels that might cause long term health effects. Exposure to dioxin-like compounds involves a complex mixture with a common mechanism of action involving endocrine, developmental, carcinogenic, immuno and neurological effects. Risk assessment is done with an additive model for mixture toxicity. Based on this the Toxic Equivalency (TEQ) concept was developed as a biomarker for exposure and risk. TEQs are the sum of congener-specific toxic equivalency factors (TEFs) multiplied by the concentration in a matrix, e.g. blood. TEF values are a composite quantitative value from a range of biomarkers that are congener and endpoint specific. Present human TEQs have been derived from oral administration experiments providing intake TEFs. Regulatory authorities frequently use intake TEQs for blood and tissues considering it a biomarker for exposure or effect. Experimental evidence shows that using uptake TEQs as systemic biomarkers may lead to misinterpretation of risks. Therefore, development and validation of systemic TEFs and TEQs as biomarkers is necessary. Major objectives of SYSTEQ are: - establish systemic TEFs and TEQs, - identify novel quantifiable biomarkers with newest molecular methods, e.g. genetic fingerprinting profiles, - extra focus on effects in peripheral lymphocytes as biomarkers, - identify differences between humans and experimental species. The systemic TEFs and TEQs from SYSTEQ will be used in conjunction with results of the completed EU PCBRISK project, in which two populations from Slovakia with very different exposure were studied. Individual blood levels and different biomarkers are already available.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: 2,3,7,8-Tetrachlordibenzo-p-Dioxin ? Biphenyl ? Dioxin ? Verbundwerkstoff ? Kanzerogenität ? Biomarker ? Gesundheitliche Auswirkungen ? Aufsichtsbehörde ? Genetik ? Polychlorierte Biphenyle ? Tracer ? Zusatzstoff ? Blei ? Slowakische Republik ? Behörde ? Komplexverbindung ? Wirkung ? Mischungstoxizität ? Blut ? Exposition ? Risikoanalyse ? Stoffgemisch ? Toxizität ? Wirkung ? Verwaltung ? Bevölkerung ? Lebensmittel ? Nahrungskette ? Umweltschutz ? Risiko ? Risikobewertung ? FP7-ENVIRONMENT ? Konzentrat ? Art [Spezies] ? gene profiling ? mixtures ? species differences ? toxic equivalencies ? Genetischer Fingerabdruck ?
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2009-02-01 - 2013-11-30
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