Description: Das Projekt "The Human Early-Life Exposome novel tools for integrating early-life environmental exposures and child health across Europe (HELIX)" wird vom Umweltbundesamt gefördert und von Fundacio Centre de Recerca en Epidemiologia Ambiental - Creal durchgeführt. The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on major child health outcomes (growth and obesity, neurodevelopment, immune system), thus developing an Early-Life Exposome approach. HELIX uses six existing, prospective birth cohort studies as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects. Results will be integrated with data from European cohorts (greater than 300,000 subjects) and registers, to estimate health impacts at the large European scale. HELIX will make a major contribution to the integrated exposure concept by developing an exposome toolkit and database that will: 1) measure a wide range of major chemical and physical environmental hazards in food, consumer products, water, air, noise, and the built environment, in pre and postnatal periods; 2) integrate data on individual, temporal, and toxicokinetic variability, and on multiple exposures, which will greatly reduce uncertainty in exposure estimates; 3) determine molecular profiles and biological pathways associated with multiple exposures using omics tools; 4) provide exposure-response estimates and thresholds for multiple exposures and child health; and 5) estimate the burden of childhood disease in Europe due to multiple environmental exposures. This integration of the chemical, physical and molecular environment during critical early-life periods will lead to major improvements in health risk and impact assessments and thus to improved prevention strategies for vulnerable populations.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Biopharmazeutikum ? Gesundheitsgefährdung ? Biomarker ? Physiologie ? Gesundheitsschaden ? Kleinkind ? Kombinationswirkung ? Pharmakokinetik ? Säugling ? Schadstoffbelastung ? Blei ? Bundesrepublik Deutschland ? Gesundheitliche Auswirkungen ? Kohortenstudie ? Mehrfachexposition ? Geografisches Informationssystem ? Kind ? Statistisches Modell ? Umweltbelastung ? Luftverschmutzung ? Molekulare Epidemiologie ? Studie ? Epidemiologie ? Gravidität ? Analyseverfahren ? Toxikologie ? Toxizität ? Verbraucherprodukt ? Umweltgefährdung ? Wasserverschmutzung ? Wirkungsanalyse ? Lärm ? Lärmbelastung ? Wasser ? Biologische Aktivität ? Chemikalien ? Menschliche Gesundheit ? Nervensystem ? Europa ? Gesundheitsbezogene Umweltbeobachtung ? Expositionsanalyse ? Immunsystem ? Kindergesundheit ? Daten ? Bevölkerungsstruktur ? Exposition ? Statistik ? Ökologischer Faktor ? Population ? Datenbank ? Datenerhebung ? Gebaute Umwelt ? Schwellenwert ? Ernährung ? Krankheit ? Umwelt und Gesundheit ? Fernerkundung ? Bevölkerung ? Lebensmittel ? Belastungsanalyse ? Umweltbedingte Krankheitslast [EBD] ? Wachstum [biologisch] ? Adipositas ? Zeitverlauf ? FP7-ENVIRONMENT ? Lebensabschnitt ?
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2013-01-01 - 2017-12-31
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