Description: Das Projekt "Exploiting contaminant degrading communities for production of novel drugs, activity mining and metabolic network manipulations Synergy between Environmental and Medical Biotechnology" wird vom Umweltbundesamt gefördert und von Helmholtz-Zentrum für Infektionsforschung GmbH durchgeführt. MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability will be assessed as to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of PAH pollution. We will generate a knowledge base not only on the microbial catabolome for biodegradation of PAHs in various impacted environmental settings based on genome gazing, retrieval and characterization of specific enzymes but also on systems related bioavailability of contaminant mixtures. MAGICPAH takes into account the tremendous undiscovered metagenomic resources by the direct retrieval from genome/metagenome libraries and consequent characterization of enzymes through activity screens. These screens will include a highend functional small-molecule fluorescence screening platform and will allow us to directly access novel metabolic reactions followed by their rational exploitation for biocatalysis and the re-construction of biodegradation networks. Results from (meta-) genomic approaches will be correlated with microbial in situ activity assessments, specifically dedicated to identifying key players and key reactions involved in anaerobic PAH metabolism. Key processes for PAH metabolism particularly in marine and composting environments and the kinetics of MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability will be assessed as to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of PAH pollution. We will generate a knowledge base not only on the microbial catabolome for biodegradation of PAHs in various impacted environmental settings based on genome gazing, retrieval and characterization of specific enzymes but also on systems related bioavailability of contaminant mixtures. MAGICPAH takes into account the tremendous undiscovered metagenomic resources by the direct retrieval from genome/metagenome libraries and consequent characterization of enzymes through activity screens. These screens will include a high-end functional small-molecule fluorescence screening platform and will allow us to directly access novel metabolic reactions followed by their rational exploitation for biocatalysis and the re-construction of biodegradation networks. Results from (meta-) genomic approaches will be correlated with microbial in situ activity
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Fluoreszenz ? Kompost ? Tierhaltungsanlage ? Genom ? Synergistische Wirkung ? Gemeinschaftskompostierung ? Abfallbehandlung ? Anaerobe Bedingungen ? Arzneimittel ? Buchhaltung ? Kompostierung ? Polyzyklische aromatische Kohlenwasserstoffe ? Schadensvorsorge ? Kompostierungsanlage ? Aerober Abbau ? Enzym ? Marines Ökosystem ? Schmutzstoff ? Übriger Bergbau ? Bakterien ? Biologischer Abbau ? Abgrabung ? Arzneimittelrückstand ? Biotechnologie ? Bioverfügbarkeit ? Isotop ? Mensch ? Stoffgemisch ? Studie ? Meeresgewässer ? Produktion ? Verunreinigung ? in situ ? Persistenz ? Ressource ? Stoffwechsel ? Abbau ? Umwelt ? Beschreibung ? Buchgrundstück ? Ergebnis ? Umgestaltung ? Verarbeiten ? Verhältnis ? Zugang ? bewerten ? gebraucht ? Gemeinschaft ? Leistungsfähigkeit ? gemischt ? neu ? spezifisch ? Raster ? unter ? verwandt ? Sieb ? Siebung ? Bahnsteig ? Basen [chemisch] ? Ausbeutung ? Bibliothekswesen ? Stall ? Biologische Aktivität, Mikroorganismen ? Annäherung ?
Region: Lower Saxony
Bounding box: 9.16667° .. 9.16667° x 52.83333° .. 52.83333°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2010-04-01 - 2014-03-31
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