Description: Das Projekt "Modelling basis and kinetics of nanoparticle interaction with membranes, uptake into cells, and sub-cellular and inter-compartmental transport (NANOTRANSKINETICS)" wird vom Umweltbundesamt gefördert und von University College Dublin, National University of Ireland durchgeführt. Objective: The prediction of biological (and in particular toxicological) impacts has, as its basic pre-requisite, the correct prediction of the sites of action and localization of the nano-particle in living organisms. We have identified the need for a paradigm shift in modelling these properties for nano-scale objects. The interactions between bare particles and organisms (cells, biological barriers) is radically different in the presence of proteins and lipids derived from the biological environment (the protein corona). The bare particle characteristic is therefore insufficient to describe the system. Similarly, nano-particles are trafficked and translocated between sites by active biological processes where traditional equilibrium principles for small molecules no longer apply. Nano-TransKinetics is firmly based on advanced high quality experimental data on the distribution of nano-particles in cells, across barriers, and (more limited) in vivo. We frame phenomenological models in a modular manner by abstracting the essential relevant principles of particle-protein (and matrix) interactions, cellular and barrier transport mechanisms of nano-particles, fitting them to experimental data. More detailed models allow for explicit checking of mechanisms and movements of individual particles into cells and across barriers. Enormous amounts of experimental data are now available to validate the models. A predictive capacity requires only simple input data on particle, corona and similar characteristics. The basis of these claims has been checked in preliminary studies, and a limited number of interactions, particles fluxes (and control parameters) between prescribed sites are sufficient to specify the system at each level of description. Resources (reaching far beyond the program itself) have been mobilised in experimental work in the Partners laboratories, and EU and US collaborations. The output will be predictive tools for use in nano-safety research and regulation and beyond.
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Biopharmazeutikum ? Corona-Pandemie ? Lipid ? Irland ? Regulierung ? Prognose ? Daten ? Emission ? Rechtsverfahren ? Protein ? Standortwahl ? Studie ? Zelle ? Modellierung ? Wirkung ? Nanopartikel ? Arbeit ? Verkehr ? Bedarf ? Forschung ? Forschungseinrichtung ? Kenngröße ? Organismen ? Partikel ? Ressource ? Sicherheit ? Umwelt ? Membran ? Tatbestand ? VERTEILUNG ? EINGESCHRAENKT ? Wechselwirkung ? EINSATZ ? BEWERTEN ? Werkzeug ? BETRAG ? FORTSCHRITTLICH ? FP7-NMP ? VERFRACHTUNG ? Betriebsvorschrift ? GRUNDSAETZE ? GRUNDSATZ ? Buchgrundstück ? KONTROLLE ? LEISTUNGSFAEHIGKEIT ? VERFUEGBAR ? MECHANISMEN ? Muskelarbeit ? Nanotechnology and Nanosciences ? Ortsbestimmung ? PROGRAMMIERUNG ? Radikal [Chemie] ?
License: cc-by-nc-nd/4.0
Language: Englisch/English
Time ranges: 2011-11-01 - 2014-10-31
Webseite zum Förderprojekt
http://www.nanotranskinetics.eu/ (Webseite)Accessed 1 times.