Description: Das Projekt "Neonatale PCB-Exposition und Defizite in der Entwicklung des Nervensystems: Einbeziehung der Gruppe mit hohem Risiko zur Ergaenzung laufender neuropaediatrischer Untersuchungen" wird vom Umweltbundesamt gefördert und von Universität Düsseldorf, Medizinisches Institut für Umwelthygiene durchgeführt. It is planned to recruit about 200 neonates at the National Hospital at Torshavn, Faroe Islands, to measure PCB-concentrations (3-6 congeners) in cordblood and spot milk samples, as well as methylmercury in maternal hair, and to follow the neurobehavioural development of these infants according to the Dutch/German study protocol as follows: Early neurological examination according to the neurological optimality concept of TOUWEN/PRECHTL at about age 15 days, cognitive examination by means of the BAYLEY-Scales of Infant Development (MDI and PDI for mental and psychomotor development, respectively), as well as by means of the FAGAN-test of Infant Intelligence, and by vocalization analysis at seven month of age, and, again, the TOUWEN/PRECHTL neurological examination and the BAYLEY-Scales at 18 months of age. Clinical training and analytical ringtests will be implemented to ensure inter-laboratory and inter-study comparability of outcome. Results will be evaluated by means of multiple regression analysis taking confounding (social status, maternal intelligence, etc) into account. The results will be combined with the Dutch/German study in order to increase the statistical power both for effect monitoring and for validation purposes as well.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Düsseldorf ? Methylquecksilber ? Arsen ? Kleinkind ? Polychlorierte Biphenyle ? Ringversuch ? Säugling ? Schadstoffwirkung ? Island ? Neurotoxizität ? Regressionsanalyse ? Krankenhaus ? Insel ? Haaranalyse ? Wirkungsmonitoring ? Energie ? Monitoring ? Nervensystem ? Risikoanalyse ? Studie ? Toxikologische Bewertung ? Toxische Substanz ? Umwelthygiene ? Gesundheitsstatistik ? Empirische Untersuchung ? Gesundheit ? Soziale Gruppe ? Schadstoff ? BAYLEY-Skala ? FAGAN-Test ? Faeroeer ? Quecksilberalkyl ?
Region: Nordrhein-Westfalen
Bounding box: 6.76339° .. 6.76339° x 51.21895° .. 51.21895°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 1994-06-01 - 1996-05-31
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