Description: Das Projekt "Teilprojekt C" wird vom Umweltbundesamt gefördert und von Universität Rostock, Institut für Informatik, Lehrstuhl für Systembiologie und Bioinformatik durchgeführt. The main aim of the proposal is to examine how different DNA double strand breaks (DSBs) influence the type of DSB repair pathway chosen and the generation of processing errors that cause cell death and genomic instability. In this project, the University of Rostock (URO) will perform bioinformatics analyses and combine different network inference methods to investigate the impact of DSB on cellular response. Firstly, publically available high throughput gene expression datasets will be pre processed and analyzed to elucidate genomic alterations resulting from radiation. Then, a regulation network derived from the previously identified differentially expressed genes and from data obtained from various databases (transcription factors, non coding RNAs, metabolomics, etc.) will be created. By doing so, the URO will develop a semi automated bioinformatics driven workflow that can then be used to predict a gene regulatory network reflecting the cellular response to radiation induced DSBs.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Rostock ? Gen ? Genom ? Genregulation ? DNA ? Genetik ? Datenverbund ? Main ? Bestrahlung ? Strahlung ? Analyseverfahren ? Strand ? Zelle ? DNA-Analyse ? Reparatur ? Datenbank ? Walstrandung ? Genexpression ?
Region: Mecklenburg-Western Pomerania
Bounding box: 12.5° .. 12.5° x 53.83333° .. 53.83333°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2015-07-01 - 2018-06-30
Webseite zum Förderprojekt
https://www.tib.eu/de/filter/?repno=02NUK043C (Webseite)Accessed 1 times.