Description: Das Projekt "Entwicklung und Prüfung von Membranen fuer Biohybridsysteme" wird vom Umweltbundesamt gefördert und von GKSS-Forschungszentrum Geesthacht, Standort Geesthacht, Institut für Chemie durchgeführt. Biohydrid Organs (BHOs) for the replacement of the essential functions of an injured kidney, liver and pancreas for long term use are not currently available. The principle reason is due to the fact that primary organ cells loose their function in vitro within a period of a few days. Immobilisation of these cells is currently performed an membranes that are mainly developed for other purposes and hence do not suppont the specific function of organ cells. Improved treatment of the diseases mentioned previously by BHOs would result in decreased morbidity and mortality of patients. This in turn could reduce the overall costs to the European health care system. Hence, it can be assumed that there is a remarkable need for improved membranes that can be used in BHOs. The development of membranes with biospecific functionality and high biocompatibility within the European Community could improve the competitiveness of European biomedical industry. It is the main objective of this project to develop membranes with sufficient transport properties that specifically support the attachment and function of kidney epithelial cells and hepatocytes by the covalent immobilisation of biogenic ligands. Flat membranes and hollow fibres based on polyacrylonitrile and polysulfone will be prepared with a cut-off up to 300 kDa to allow the transport of ions, nutrients, waste products, protein-bound toxins and also to protect xeno/allogenic cells from the host immune system. The membranes will be functionalised and modified by wet and dry surface chemistry. Biospecific ligands will be covalently bound to support the attachment and function of kidney epithelial cells or primary hepatacytes an one side of the membrane and to achieve a good haemocompatibility an the other blood contacting side of the membrane. It both properties cannot be combined in one membrane, replacement can be achieved by the application of a specific fibre-in-fibre design for hollow fibres. Knowledge of the production and modification of suitable membranes on a lab-scale will be used for upscaling to allow the production of those membranes in larger quantities. The consortium comprises of a leading research institute with long experience in polymer synthesis and membrane formation; a company (SME) dealing with different surface modification techniques for improved biocompatibility of polymers; three different research institutes from universities with expertise in haemo- and tissue-compatibility and artifical organs and one campany producing membranes and equipment for haemodialysis. The composition of the consortium does not only ensure a qualified processing of the propased work, but also guarantees exploitation of the results for an improved competitiveness of the European biomedical industry and a better medical care.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Geesthacht ? Wohnung ? Nährstoff ? Polymer ? Europäische Gemeinschaften ? Main ? Abfalltransport ? Gewährleistung ? Polyacrylnitril ? Toxin ? Blut ? Immunsystem ? in vitro ? Ionen ? Morbidität ? Mortalität ? Wettbewerbsfähigkeit ? Forschungseinrichtung ? Gesundheitswesen ? Gutachten ? Krankheit ? Membran ? Organ ? Produktdesign ? Verkehrssystem ?
Region: Schleswig-Holstein
Bounding box: 9.75° .. 9.75° x 54.2° .. 54.2°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 1998-04-01 - 2001-03-31
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