Description: Das Projekt "Measurement of Cisplatin, Carboplatin, 5-Fluorouracil and Methotrexate Concentrations in Head and Neck Cancers by in vivo Microdialysis" wird/wurde ausgeführt durch: Universität für Bodenkultur Wien, Institut für Chemie.Cisplatin, carboplatin, 5-fluorouracil and methotrexate concentrations in head and neck cancers are collected by in vivo microdialysis. The Pt concentration is subsequently analysed by means of HR-ICPMS. A speciation by online coupling of a chromatographical system to the HR-ICPMS is planned. Aims of the study: 1. To describe the time versus concentration profile in tumor tissue of the study drugs as a measure of tumor exposure. 2. To compare the tissue/plasma ratios as a measure of tumor penetration. 3. To describe the time versus concentration profile in the subcutaneous adipose tissue for the study drugs as a measure of drug exposure of normal tissue.
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Origins: /Bund/UBA/UFORDAT
Tags: Platin ? Arzneimittel ? Karzinogenese ? Massenspektrometrie ? Onkologie ? Bestimmungsmethode ? Chromatografie ? Krebserkrankung ? Studie ? Tumor ? Gewebe ? 5-Fluoruracil ? Carboplatin ? Cisplatin ? HR-ICPMS ? In-Vivo ? Konzentrationsmessung ? Methotrexat ? Mikrodialyse ? On-Line-Betrieb ? Speziation [Chemie] ?
License: cc-by-nc-nd/4.0
Language: Englisch/English
Time ranges: 1997-01-01 - 2008-12-31
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