Description: Das Projekt "CEFALO: An international case-control study on brain tumours in children and adolescents" wird vom Umweltbundesamt gefördert und von Universität Bern, Institut für Sozial- und Präventivmedizin, Abteilung Internationale Gesundheit & Umwelt, Ressort Umwelt und Gesundheit durchgeführt. Background: It has been hypothesized, that children could be more vulnerable to radio frequency electromagnetic field exposures from mobile telephones than adults, but no epidemiological studies of the relationship have been performed so far. The lack of knowledge causes conflicting recommendations from decision-makers, leading to anxiety and insecurity in the population. WHO has put a case-control study on childhood brain tumours as high priority on their 2006 research agenda on radio frequency electromagnetic fields. Objectives: The main goal of the study is to investigate whether use of mobile telephones increases the risk of developing brain tumours for children or adolescents. In addition, our study will provide a comprehensive dataset to investigate other potential risk factors for childhood brain tumour. Study design: The questions under study will be investigated by means of a case-control study in Denmark, Norway, Sweden and Switzerland. Cases will be identified through a combination of registry data and information from the wards treating the patients (e.g. Swiss Paediatric Oncology Group: SPOG). All incident cases of brain tumour in the age group 7-19 years between May 2004 and April 2008 will be invited to participate. In total, the study is expected to include 550 cases of brain tumours in the participating countries, thereof 100 originating from Switzerland. For each case, two control persons will be randomly selected from the general population, matched on age, sex and geographic regions. Exposure assessment: Information on the extent of exposure to radio frequency fields from mobile phones and on other known and suspected risk factors for childhood brain tumours will be obtained by means of computer assisted personal interviews conducted by an interviewer trained for this purpose. The interviews will take place either at the hospital or at the study participant's home. Objective information on the frequency and duration of mobile phone use will be obtained from mobile phone operators and from the information stored in the telephone that is in current use. Data analyses: The data will be analyzed using established statistical methods for case-control studies, primarily via logistic regression models adjusted for potential confounding factors. In order to investigate potential gene-environment interactions, DNA from saliva samples will be extracted and analysed. Polymorphisms in genes that affect oxidative metabolism, detoxification of carcinogens, DNA stability and repair, or immune response, are candidates that might confer genetic susceptibility to brain tumors.
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Main ? Computer ? Gen ? Mobiltelefon ? Kanzerogenität ? Dänemark ? Norwegen ? Schweden ? DNA ? Genetik ? Kleinkind ? Resistenz ? Blei ? Wohngebäude ? Schweiz ? Jugendlicher ? Entgiftung ? Interview ? Kind ? Onkologie ? Krankenhaus ? Erwachsener ? Karzinogen ? Fallkontrollstudie ? Studie ? Ackerland ? Elektromagnetisches Feld ? Reparatur ? Modellierung ? Bodenprobe ? Daten ? Geographie ? Rechtsverfahren ? Expositionsanalyse ? Tumor ? Geschlecht ? Epidemiologie ? Exposition ? Lebensalter ? Gefährdungspotenzial ? Risikofaktor ? Risiko ? Stoffwechsel ? Gebiet ? Gefahr ? Forschung ? Potenzial ? Kontrolle ? Privathaushalt ? Risiken, Sicherheit ? Sicherheitsüberprüfung ? Dauer ? Aufbereiteter Boden ? Empfehlung ? Entscheidung ? Frage ? Gehirn ? Gruppe ? Konflikt ? Methode ? Mischung ? Probe ? Sicherungsanordnung ? Steuerung ? Verantwortung ? Vermehrung ? Vorgang ? Zweckbestimmung ? ausgewählt ? sonstig ? statistisch ? unter ?
License: cc-by-nc-nd/4.0
Language: Englisch/English
Time ranges: 2005-10-01 - 2008-12-31
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