Description: Das Projekt "EDEN - Endocrine Disrupters: Exploring Novel Endpoints, Exposure, Low Dose and Mixture-Effects in Humans, Aquatic Wildlife and Laboratory Animals" wird vom Umweltbundesamt gefördert und von Technische Universität München, Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Lehrstuhl für Zellbiologie durchgeführt. Objectives and expected achievements: EDEN is an interdisciplinary effort designed to address key issues that currently hamper sound hazard- and risk assessment for endocrine disrupting chemicals (EDC) in the European Union. It adopts an approach that fully integrates human, wildlife, exposures, mechanisms and low-dose/mixture-evaluations, with the following specific objectives: 1. To gather data about the composition of complex mixtures of endocrine disrupting chemicals (EDC) in human and fish tissues from different areas of the European Union. Systematic exposure assessments that provide a global view an EDC and take the mixtures issue into account, are missing. EDEN will bridge this gap by analysing tissue specimens from humans and fish that show reproductive disorders. In this way, EDEN will optimise the chances of detecting potential causal relationships and will provide a rational basis for wildlife and human risk assessment. As much as possible, the data gathered in these studies will also inform experimental mixture studies. 2. To investigate the mechanisms underlying the action of EDC in order to evaluate the relevance of existing experimental models for wildlife and human hazard assessment and to develop novel endpoints and biomarkers for the early detection of effects. The relevance of many currently used in vivo EDC assays to real existing effects in humans and wildlife is often unclear. EDEN will focus an endpoints in laboratory animals that have a clear relationship to real existing disorders in humans and fish. The project will identify key mechanisms and common pathways and will lead to the development of new cell-based, rodent and fish models, as well as clinical assays for the early detection of EDC effects. 3. To provide new insights into indicators of impaired reproductive function in European citizens and to extend and improve existing European databases. Disruption of hormone production in foetal life leads to disorders of the male reproductive system. Some of these effects are evident at birth, others become obvious only later in life. Lifelong lowering of testosterone levels may link these perinatal and adult events. Using unique and extensive collections of longitudinal human blood samples, EDEN aims to test this hypothesis. The potential link between foetal and adult disorders will also be evaluated in animal mechanistic studies by studying the effects of EDC that induce lowering of testosterone levels in foetal life. Existing databases an sperm quality will be improved by extending the analyses to European countries not previously studied. This work will open new possibilities for proving/disproving links between health and environmental exposure usw.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: München ? Nagetier ? Fisch ? Gesundheitsgefährdung ? Biomarker ? Endokrine Wirkung ? Schadstoffwirkung ? Zytologie ? Blei ? Blutprobe ? Sperma ? Endokriner Disruptor ? Ökotoxikologie ? Ökotoxizität ? Schadstoffexposition ? Umweltbelastung ? Umweltchemikalien ? Versuchstier ? Wassertier ? Wildtier ? Erwachsener ? Europäische Union ? Geschlechtshormon ? Toxizität ? Mensch ? Exposition ? Tier ? Blut ? Flächennutzung ? Hormonsystem ? Fortpflanzung ? Studie ? Wildlebende Tiere und Pflanzen ? Toxikologie ? Endokrin aktive Substanz ? Daten ? Hormon ? Expositionsanalyse ? Gewässerorganismen ? Datenbank ? Krankheit ? Risikobewertung ? Vermehrung ? Schadstoffverbleib ?
Region: Bayern
Bounding box: 12.53381° .. 12.53381° x 47.795° .. 47.795°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2002-12-01 - 2006-11-30
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