Description: Das Projekt "Neue Biosensoren fuer die verbesserte Erkennung von Umweltverschmutzung durch Anticholinesterase-Pestizide" wird vom Umweltbundesamt gefördert und von Universität Stuttgart durchgeführt. Excessive use of pesticides in Europe has led to serious contamination of soil and water and presents a growing threat to human and animal health. We propose to improve the sensitivity of biosensors used both for detecting incidental or chronic environmental contamination by anticholinesterase pesticides and for monitoring the efficiency of remediation of polluted sites. The enzyme acetylcholinesterase is the target of organophosphates and carbamates, two major pesticides currently used in agriculture. We will employ a 'state-of-the-art' approach, utilizing X-ray crystallography, structure analysis, site-directed mutagenesis and large-scale production, using suitable expression systems. This will enable us to produce new bio-engineered targets both more sensitive to and more selective for pesticides of interest, and also possessing increased stability. This will permit us to provide our industrial partner with deliverables suitable for production of novel biosensors possessing the specificity and shelf-life required for manufacturing field kits.
Types:
SupportProgram
Origin: /Bund/UBA/UFORDAT
Tags: Schädlingsbekämpfungsmittel ? Stuttgart ? Acetylcholinesterase ? Pestizid ? Carbamat ? Gesundheitsgefährdung ? Röntgenstrahlung ? Biosensor ? Altlast ? Biomonitoring ? Organische Phosphorverbindung ? Schadstoffbelastung ? Sensor ? Bodenverunreinigung ? Enzym ? Insektizidrückstand ? Kristallographie ? Pestizidbestimmung ? Pflanzenschutzmittelanwendung ? Tiergesundheit ? Toxische Substanz ? Umweltverschmutzung ? Wasserverschmutzung ? Monitoring ? Tier ? Wasser ? Europa ? Mensch ? Stand der Technik ? Systemanalyse ? Landwirtschaft ? Effizienzsteigerung ? Schadstoffnachweis ? Enzymaktivität ?
Region: Baden-Württemberg
Bounding box: 9° .. 9° x 48.5° .. 48.5°
License: cc-by-nc-nd/4.0
Language: Deutsch
Time ranges: 2000-09-01 - 2003-09-01
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