New-Generation Steroid Hormones

Description: The project generated ecotoxicological data needed for the development of a tailored testing strategy to assess the environmental risk of pharmaceuticals (progestins and glucocorticoids). For this purpose, chronic fish tests, among others, were carried out in the laboratory according to a new test protocol currently undergoing ⁠ OECD ⁠ validation investigating dienogest and dexamethasone as test substances. The studies provided reliable and valid results with effect thresholds in the lower µg/L or ng/L range. This has closed data gaps for the development of new assessment approaches for a targeted risk assessment of specifically acting pharmaceuticals. Additional investigations on directed gene expression and immunosuppressive effect assays would complement the assessment strategy for progestins and glucocorticoids. Veröffentlicht in Texte | 57/2024.

Types:

Text {
    text_type: Publication,
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Origin: /Bund/UBA/Webseite

Tags: Fischtest ? OECD ? Steroid ? Daten ? Hormon ? Studie ? Testsubstanz ? Umweltgefährdung ? Risikobewertung ?

License: other-closed

Language: Englisch/English

Organisations

• Umweltbundesamt (Herausgeber*in)

Persons

• Dr. Dirk Schaudien (Verfasser*in)
• Dr. Elke Eilebrecht (Verfasser*in)
• Dr. Kornelija Franzen (Verfasser*in)
• Dr. Matthias Teigeler (Verfasser*in)
• Prof. Dr. Christoph Schäfers (Verfasser*in)

Issued: 2024-04-01

Time ranges: 2024-04-01 - 2024-04-01

Resources

• https://www.umweltbundesamt.de/sites/default/files/medien/11850/publikationen/57_2024_texte_steroid_hormones.pdf (PDF)

Status

Aktiv

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