Das Projekt "Neue Prinzipien der Entgiftung von Phosphorsaeureestern (PE)" wird vom Umweltbundesamt gefördert und von Universität Mainz, Institut für Organische Chemie durchgeführt. Ziel der Untersuchung: Die Suche nach Reaktivatoren vergifteter Cholinesterase. Um dieses Ziel zu erreichen, soll versucht werden, mehr ueber Struktur und Wirkungsweise der Cholinesterase zu erfahren.
Das Projekt "Modellierung der oekologischen Qualitaet von Fluessen in Stadtgebieten: Oekotoxikologische Faktoren, die die Sanierung von Fischbestaenden behindern" wird vom Umweltbundesamt gefördert und von Technische Universität Berlin, Institut für Ökologie, Fachgebiet Landschaftsökologie , Ökotoxikologie durchgeführt. Objective: Problems to be solved: The objectives of the project are to determine the ecotoxicological factors limiting restoration of sustainable fish populations in polluted urban rivers. These factors will be described and modelled for urban river systems in four European countries, Italy, Germany The Netherlands and the UK. By monitoring the conditions in each river and the natural fish population, then using caged fish to sample the environmental and biological factors that limit sustainable fish populations, the project will address the problems relating to the establishment of a standardised and validated array of bio-indicator measurements, for use in water quality surveillance and monitoring schemes, in support of environmental policies for integrated water management. A parallel sociological study of risk perception in stakeholders will provide information on peoples' perceptions and expectations with regard to water. The CEC Council have as their aim the remediation of European surface and ground waters in order that they achieve 'good' ecological status by the year 2010. This project will contribute to the objectives of Key Action 1, Sustainable management and quality of water and in particular, key action 1.2, Ecological quality of freshwater ecosystems and wetlands, and specifically key action 1.2.2, Ecological quality targets. Scientific objectives and approach: At each site, the ecological quality of the study river will be described on a seasonal basis in terms of biotic indices and chemical water quality, and related to the population biology of a resident species of coarse (tolerant) fish. Sub-lethal indicators of pollution will then be measured on fish exposed to the prevailing seasonal water conditions at each site, in floating cages. A range of biochemical indicators (biomarkers) will be used to reveal specific exposure to particular contaminants or classes of contaminants. These will include: - induction of cytochrome P450 and metallothioneins; DNA damage, in terms of strand breaks; estrogenic activity (measured as vitellogenin induction); brain cholinesterase activity. Measurement of swimming performance will be used as an indicator of physiological status, revealing seasonal differences and the response to exposure to the complex changes in water chemistry, following flood spates. These measurements will be related to migration of fish within the river system, using radio-tracking or tag and recapture. The immunological status of fish (e.g. macrophage activity) will be assessed, as urban waters can be subject to elevated contents of pathogenic bacteria from human waste and, furthermore, fish in poor condition as a result of pollution and other physico-chemical stresses may have compromised immune competence. Prime Contrator: University of Birmingham, School of Biological Sciences; Birmingham.
Das Projekt "Diagnose und Therapie der Organophosphat- und Carbamatvergiftung bei der Taube (Columba livia f. domestica)" wird vom Umweltbundesamt gefördert und von Tierärztliche Hochschule Hannover, Klinik für Geflügel durchgeführt. Erstellung von Referenzwerten der Plasma-Cholinesterase (Butyrylcholinesterase) der Taube fuer das trockenchemische VitrosDT-Analysesystem in Abhaengigkeit von Geschlecht, Jahreszeit, Reproduktionszyklus und Nestlingsalter; Ueberpruefung der Praxistauglichkeit der diagnostischen Enzymreaktivierung durch Obidoximzusatz bzw. Verduennung (bei Carbamatintox.); Einsetzbarkeit von Obidoxim in der Therapie.