Das Projekt "Omics-basierte Analysen von Pflanzenstoffwechselveränderungen aufgrund gentechnischer Veränderung in gv-Kulturpflanzen - unter Berücksichtigung von Stresseinwirkung und Auswirkungen für die GVO-Sicherheitsbewertung in der Vollzugspraxis" wird vom Umweltbundesamt gefördert und von Genok - senter for biosikkerhet durchgeführt. The concept of substantial equivalence has long being used in safety testing of GMO crops, but the term and the concept has no clear definition. Currently, the common practice has been the investigation of compositional and nutritional substances in the GMO. However, unintended changes in the GMO might not be identified by the analysis of such small number of components. It is an evolving view among regulators that omics techniques, such as proteomics and metabolomics, can be used to complement analytical tools to existing safety assessment procedures. Therefore, this project is about the application of omics technologies to investigate potential unintended metabolic alterations in genetically modified plants and for elaboration of their relevance for GMO risk assessment. In particular, metabolic disturbances will be investigated when different transgenic inserts are combined in a single plant (stacking), and when these plants are exposed to abiotic stressors, such as herbicide application and drought. The project is divided into three working packages each containing experiments to address specific research questions.