Das Projekt "Improve tools and strategies for the prevention and control of classical swine fever (CSFV_goDIVA)" wird vom Umweltbundesamt gefördert und von Helmholtz-Zentrum für Umweltforschung GmbH - UFZ, Department Ökologische Systemanalyse durchgeführt. Although classical swine fever (CSF) has been eradicated in wide areas within the EU the disease is endemic in some new member states particularly in back yard pigs. In order to improve the eradication strategies the project aims are - the final development and testing of a live marker vaccine candidate for the prevention and improved control of CSF, both orally and intramuscularly applicable; - the development and optimisation of accompanying discriminatory diagnostic tests; - the production of an effective, oral delivery system for the marker vaccine for use in wild boar and back yard pigs; - the easy selection of diseased animals. The improved knowledge on immunological reactions and pathogenesis will support a more efficient vaccine application and provide data for the epidemiological models. Epidemiological studies of CSF in domestic and back yard pigs and in wild boar including molecular epidemiology intend to increase the insight of CSF transmission and persistence. Epidemiological models will be developed to support risk assessment as well for conventional eradication strategies as for new strategies using the new vaccines and diagnostic tools including the role of CSF reservoirs. The results concerning anti-viral treatment will be evaluated and compared with the traditional eradication strategies. Prime Contractor: Centrum voor Onderzoek in Diergeneeskunde en Agrochemie - CODA; Bruxelles, Belgien.